It is found that respiratory virus evades the attack mechanism of immune system

Researchers in the United States have found a mechanism by which common respiratory viruses escape from the human immune system, which is expected to be used in the development of vaccines against common respiratory virus infections in the future "Human metapneumovirus" is the second common cause of respiratory tract infection in children and the elderly in the world, next to another single strand RNA virus of the same genus, respiratory syncytial virus According to research published in the British journal Nature microbiology on February 3, "human metapneumovirus" can escape the attack of innate immune response through a common RNA methylation modification (m6A) Researchers at Ohio State University in the United States found that after methylation modification, human partial lung virus successfully reduced the recognition ability of immune protein to virus RNA, thus escaping the attack of immune system The researchers found that after knockout of the modification, the variation produced by the virus can induce a stronger innate immune response, which is essential for the body to form an adaptive immune response to specific pathogens Animal experiments on cotton mice show that the mutant virus can be used as a "human partial lung virus" vaccine, which can effectively prevent cotton mice from infection and trigger a stronger innate immune response and an effective adaptive immune response Since the methylation modification may also exist in other viruses, the discovery could also provide clues for the development of "respiratory syncytial virus" and other virus vaccines, the researchers said