It is found that soybean extract has the effect of inhibiting the occurrence of breast cancer

Under normal conditions, there are estrogen receptors on the surface of breast cells, which can be affected by estrogen to regulate cell growth With drugs targeting the receptor (http:// doctors can deliver chemotherapy drugs to kill target cells However, for most breast tumors, the absence of this receptor leads to the ineffective use of chemotherapy drugs For cancer cells without estrogen receptors, drugs targeting the other two types of receptors are needed However, there is no effective chemotherapy for breast cancer cells lacking all three kinds of receptors, so-called "three negative breast cancer" Recently, in the journal Current developments in nutrition, researchers from the University of Arizona Cancer Center found that genistein, a dye extracted from soybeans, has the effect of inhibiting breast cancer The results showed that dyestuff wood brass could protect the stability of BRCA1 gene, while the latter played an important role in the occurrence of breast cancer BRCA1 BRCA1 is a kind of tumor suppressor gene Under normal circumstances, it can keep the stability of DNA and prevent a series of diseases such as cancer When brac1 is abnormal, the body's ability to resist cancer will decline Although a few breast cancers are caused by brac1 mutations, methylation modification will still occur, which will affect the activity of breast cancer The "silencing" of brac1 gene makes it lose its function as a tumor suppressor gene Some carcinogenic factors in the environment, such as smoke, ultraviolet light and so on, will lead to the activation of the AhR receptor on the cell surface, further inhibit the activity of the brac1 gene, and ultimately lead to the occurrence of cell carcinogenesis These compounds found in soybeans have the effect of targeting the AhR receptor to block the activity At present, the cell level experiment has been successful Researchers are using the mouse model of breast cancer to carry out in vivo research If the results meet the expectations, they will further promote the clinical trials (http://