It is revealed that HECTD3 may become a new target for anti-infection.

The type I interferon signaling pathway plays an important role in the host's resistance to pathogen infection, weakening body damage and preventing the occurrence of autoimmune diseases, so the production of type I interferon in the host body is carefully regulated by a mechanism to ensure a moderate immune response.
ubiquitin modification plays an important role in viral infection-induced IFN-I production and anti-viral infection, but the regulatory mechanism of pathogen infection is relatively few research, and the role of IFN-I in host resistance to different pathogen infections is not clear.
HECTD3 is an E3 ubiquitin joinula belonging to the HECT family, and there is little research on the protein.
research by Chen Zeshi, a researcher at kunming Zoological Research Institute of the Chinese Academy of Sciences, confirmed that HECTD3 is highly expressive in breast and prostate cancer, promotes tumor cell resistance to chemotherapy drugs, and increases the survival of tumor cells (Li et al. Cell Death Dis, 2013; Li et al. Neoplasia, 2013); and established a mouse model of the Hectd3 gene knockout.
on this basis, Chen Tse-siand and the Kunming Animal Institute Qi Xiaopeng team, revealed that HECTD3 plays an extremely important role in the host's innate immune response.
Mice with Hectd3 gene-defective type significantly enhanced the host's resistance to intracellular replication pathogens such as Francis, bacillus tuberculosis and listeria, mainly through the transmission and spread of intracellular bacteria.
its intrinsic molecular mechanism is HECTD3 can mediate TRAF3 K63 chain polyphertation to promote the production of type I interferon.
the missing macrophages of the Hectd3 gene significantly reduced gene expression induced by the type I interferon signaling pathway under Francis infection conditions, thereby inhibiting the spread and spread of Francis bacteria in the body, and Mice with Hect3 gene-defective type showed significant resistance to infection, suggesting that HECTD3 could become a new target for anti-infection.
the study, which was published online June 19 in the international journal Journal of Clinical Research, with the theme heCTD3 mediated and type I IFN inthetaly, the project. Li Fubing, Li Yang, Liang Huichun and Xu Tao of the Kunming Animal Institute,
, are co-authors of the article, and Qi Xiaopeng and Chen Tsing-shi are co-authors of the article.
the work has been supported by the Ministry of Science and Technology's key research and development program, the Chinese Academy of Sciences and the National Natural Science Foundation of China.
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