It is revealed that sirt5 regulates the physiological function and function mechanism of brown fat differentiation in the Sirtuins family.

On April 22, the international journal Diabetes published the results of the study of THE researchers of Li Jingya of the Shanghai Institute of Pharmaceutical Research of the Chinese Academy of Sciences and the Li Jia team on SIRT5's involvement in regulating brown fat differentiation.
this study reveals the physiological function and function mechanism of SIRT5 regulating brown fat differentiation in the Sirtuins family, further expands the link between epigenetics and fat biology, deepens the understanding of epigenetic mechanism to regulate fat differentiation, and provides a new way of thinking to fight obesity.
brown fat and beige fat can increase the body's energy consumption through non-thriller production heat, thus becoming a hot topic in anti-obesity research.
brown, beige fat differentiation and heat production activity are regulated by a series of transcriptional regulatory factors and epigenetic regulatory factors, and many scientific studies have focused on finding small molecular compounds or important regulatory factors that promote brown fat differentiation and browning of white fat.
the physiological function and mechanism of sirtuins family members has been one of the hot topics in the field of metabolic research, but unlike other members of the family, SIRT5 has strong deamberylation enzyme activity.
Li Jingya's team first discovered the important role of SIRT5 in regulating brown fat differentiation, confirming that SIRT5 is necessary for brown fat cell differentiation.
studies found that SIRT5 affects the concentration of intracellular metabolites alpha-KG, further leading to the differentiation of the key transcription factors Ppar and Prdm16 gene promoter region H3K9 methylation modification changes, thus playing a regulatory role.
overall animal tests showed significant impairment in sirT5's ability to knock out white fat under the skin of mice.
(A) knocking down SIRT5 causes damage to C3H101/2 cells to brown fat differentiation; (B-E) knocks down SIRT5 causing Ppar and Prdm16 gene promoter regions H3K9me2 and H3K 9me3 increase; (F) SIRT5 knockout of cold stimulation intolerance in mice; (G) SIRT5 knockout mice subcutaneous fat browning significantly reduced; (H) cold stimulation under SIRT5 knockout mice subcutaneous fat concentration significantly reduced a-KG concentration.
the study's co-authors are Li Jingya and Li Jia of the Shanghai Institute of Medicine, and the first authors are Dr. Shuai Lin, Ph.D. Zhang Lina and Ph.D. student Li Bohan.
the research was supported by the National Natural Science Foundation of China, the National Major Scientific Research Program and the Shanghai Science and Technology Commission Foundation, as well as the support and assistance of researchers Tan Minjia, Zhao Yingming and Dr. Liu Jia of the Shanghai Institute of Pharmaceuticals.
the weight loss effect of brown fat from where the body's white fat is mainly used for energy storage, while brown fat is responsible for consuming energy to heat up, helping to lose weight.
scientists have discovered the molecular mechanismbehind brown fat's energy consumption, providing new ideas for treating obesity-related diseases. A molecule called estrogen-related receptor gamma is key to energy consumption for brown fat,
researchers at the Salk Institute for Biological Research and other institutions, in a new issue of the journal Cell Reports.
they found that brown fat cells expressed the "estrogen-related receptor gamma" gene at any time, while white fat did not.
the removal of the genes prevented mice from producing "estrogen-related receptor gammaes", the brown fat in their bodies became similar to white fat, and mice were unable to maintain body temperature at low temperatures.
experiments have shown that "estrogen-related receptor gamma" is the key to allowing brown fat to consume energy and maintain the ability to stay warm.
researcher Ronald Evans says the new findings not only improve understanding of how the body is protected from the cold, but also provide a new way to regulate brown fat in the body.
researchers plan to test whether some white fats can have brown fat function by activating the "estrogen-related receptor gamma" in white fat, providing new ideas for the treatment of obesity and diabetes.
Source: Xinhua.com Zhou Zhou, Shanghai Institute of Drug Research.