It is revealed that the molecular mechanism of 5'UTR regulated translation is revealed: trans-cut genes have higher translation efficiency.

Genes are widely regulated at the translation level.
5'UTR participation in translation is considered to be a key element of translation regulation.
because of the difficulties in the experiment of high-volume modification gene 5'UTR sequence, the regulation mechanism of 5'UTR on translation is still unclear.
ne worm can change the 5'UTR length of 70% of endogenic genes, so it is a natural experimental system for studying this scientific problem.
Qian Wenfeng of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, by analyzing the data of the Translation Group (Ribo-seq), found that trans-cut genes have higher translation efficiency.
, in collaboration with the Du-Soo Research Group, studied the key points of trans-cutting mutations and observed that mutants had lower translation efficiency.
further research shows that trans-cutting is mainly achieved by reducing the upstream starting code (uAUG) in 5'UTR and weakening the secondary structure of mRNA.
the study reveals the molecular mechanism of 5'UTR regulation translation, which lays the foundation for further study of translation level regulation.
the above findings were published on September 1st in GeneMe Research (DOI: 10.1101/gr.202150.115).
Yang Yufei, a former assistant researcher in Qian Wenfeng Research Group, Zhang Xiaoqing, a doctoral student, Ma Xuehua, an assistant researcher in Du's research group, and Zhao Taolan, a postdoctoral fellow in Qian Wenfeng's research group, were the co-authors of the article.
Du and Qian Wenfeng are co-authors of this article.
research has been funded by the National Natural Science Foundation of China and the Chinese Academy of Sciences strategic pilot science and technology special.
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