It was found that sirt4 protein in Drosophila plays an important role in life span

Recently, published in the journal PNAs, scientists from Brown University have found that the increased sirt4 protein in Drosophila can prolong the life span of Drosophila The study also showed that the lack of sirt4 protein would increase the sensitivity of Drosophila to hunger, reduce its fertility and activity ability, and be unable to transfer the energy stored in the body Therefore, enhancing sirt4 protein activity is expected to be an important way to treat age-related metabolic diseases Sirt4sirt4 was first found in mitochondria and belongs to a class of proteins called sirtuins Studies have shown that sirtuins are related to longevity, metabolism, genomic stability, diabetes, neurodegeneration and so on The team found that when sirt4 was overexpressed, the mutant flies' health (http:// life expectancy increased by 20% On the contrary, if sirt4 expression is inhibited, the life span will be reduced by 20% Through these studies, the researchers say that the biological changes brought about by changing the expression of SIRT 4 may also apply to humans