It was found that soluble fatty acid binding protein released from adipose tissue can promote the development of obesity related breast cancer

As we all know, obesity can increase the risk of multiple cancers, including breast cancer In the latest issue of cell me tabolis, Bing Li, a Chinese scientist from the University of Louisville in the United States, found that the soluble fatty acid binding protein released by adipose tissue can promote the development of obesity related breast cancer In this study, researchers reported that fatty acid binding protein A-FABP in the circulatory system promotes the development of obesity related breast cancer Using clinical samples, the researchers found that obese breast cancer patients had significantly higher levels of A-FABP in their circulatory system than those without breast cancer Further studies have shown that A-FABP in the circulatory system is released from adipose tissue, which can directly target breast cancer cells, enhance tumor dryness and invasiveness, and this effect is achieved by activating the IL-6 / STAT3 / ALDH1 pathway The study also found that knockout of A-FABP in different mouse models can successfully inhibit the activation of tumor ALDH1 and the growth and development of obesity related breast tumors These results suggest that A-FABP in the circulatory system is an associated factor between obesity and breast cancer risk, which also suggests that A-FABP may be a new target for the treatment of obesity related cancer.