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    Home > Active Ingredient News > Drugs Articles > It was found that the increase of iron content in lung was a risk factor of fungal infection in lung transplantation patients

    It was found that the increase of iron content in lung was a risk factor of fungal infection in lung transplantation patients

    • Last Update: 2018-02-24
    • Source: Internet
    • Author: User
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    Aspergillus fumigatus is a very common mold, which still exists in hospitals with strict sanitary environment Aspergillus fumigatus infection is one of the most important causes of death in lung transplant patients Recently, published in the latest issue of the journal Science tranlatio nal medicine, researchers from Stanford University School of Medicine found that the increase of iron content in the lung was a risk factor for fungal infection in lung transplant patients The researchers want to understand the key factors that cause Aspergillus fumigatus to invade the body By establishing a mouse lung transplantation model, the authors found that the implanted lung would deposit excessive iron, which also existed in human lung transplantation samples The researchers further found that the increase of iron level would promote the invasion of Aspergillus fumigatus In other words, with the increasing level of iron, the depth of fungal invasion is also increasing This result indicates that the content of iron may be the key to Aspergillus fumigatus infection In addition, the difference of iron level in the transplanted tissues of different patients also determines the risk of Aspergillus fumigatus infection.
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