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1 , Hp Overview
1 , Hp Overview 1 , Hp OverviewHelicobacter pylori, referred to as Hp, Helicobacter pylori, habitually called Helicobacter pylori, H.
pylori, the bacteria has 2-6 flagella, it is the only bacteria that can survive the strong acid environment of the stomach, living under the gastric mucosa Between the epithelium of the gastric mucosa and the epithelium of the gastric mucosa, it can actively invade mucosal epithelial cells
.
pylori, the bacteria has 2-6 flagella, it is the only bacteria that can survive the strong acid environment of the stomach, living under the gastric mucosa Between the epithelium of the gastric mucosa and the epithelium of the gastric mucosa, it can actively invade mucosal epithelial cells
.
H.
pylori can cause chronic mucosal inflammation through many ways such as bacteriology, cytotoxicity, and immune activation.
Over time, it manifests as epithelial damage in anatomy.
Repeated damage causes glands to wither, which in turn leads to gastric mucosal atrophy.
The probability and severity of mucosal atrophy will increase, the mucosa becomes thinner, and the new epithelial intestinal metaplasia is caused by repeated infections of H.
pylori or repeated infections
.
Intestinal metaplasia is considered to be the adaptive response of the gastric mucosa to long-term unfavorable environments, and the heterogeneous intestinal epithelium further develops abnormally during the regeneration process, forming atypical hyperplasia, manifested as cell atypia and glandular structural disorder.
H.
Not all H.
pylori patients have gastric cancer as the final outcome.
From a genetic perspective, the most important carcinogenic gene in H.
pylori is the cag gene.
Only H.
pylori with cag islands will further promote gastric epithelium.
Cells secrete some inflammatory factors, activate tumor signals and eventually develop into cancer
.
Personal genetic sensitivity, physical fitness, and living habits will all affect the progression of the disease
Not all H.
2.
Note:
a Standard dose of proton pump inhibitor + standard dose of bismuth ( 2 times /d , orally before meals) + 2 kinds of antibacterial drugs (orally after meals)
.
Standard-dose proton pump inhibitors are esomeprazole 20mg , rabeprazole 10mg (or 20mg ), omeprazole 20mg , lansoprazole 30mg , pantoprazole 40mg , ilaprazole 5mg , and more Choose one; the standard dose of bismuth is 220mg of bismuth potassium citrate (standard dose of pectin bismuth to be determined); b The curative effect is graded according to Graham : grade C is 85%-90% , grade B is 90%-94% except for levofloxacin the program is not the first time as an external treatment program 14 d 14 d even if H.
pylori after complete cure can not relax, if not pay attention, there is still the possibility of recurrence
.
References: .
Hanbao Hai Hp and digestive Progress tract disease relationships [J] Chinese Urban and Rural Industrial, 2020, 35 (04): 51-4 digest in this message
