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J Autoimmun: Phosphatase controls cytokine-mediated overproduction of galactose-deficient IgA1 ( the main autoantigen for IgA nephropathy )

 Last Update: 2022-09-07
 Source: Internet
 Author: User

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Background: IgA nephropathy (IgAN) is an autoimmune disease characterized by the deposition

Methods and results: The team found that cytokine stimulation increased Gd-IgA1 production in B cells of IgAN patients in peripheral blood mononuclear cells (PBMCs), but not in B cells in healthy control groups (p< 0.

Conclusions: These results suggest that a specific subset of IgA1-secreting cells may be responsible for the production of autoantacts in IgAN due to cytokine-mediated abnormal signaling regulation, a process that may occur in the inflammatory response in

Source: Reily C, Rice T, Crossman DK, Rizk DV.

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