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J Cell Physiol: Histoprotein demethylase KDM7A is necessary for breast cancer stem cell maintenance and apoptosis suppression.

 Last Update: 2020-10-12
 Source: Internet
 Author: User

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Histoprotein demethylase KDM7A is known to regulate neuron differentiation and development in mammals.
study, we found that KDM7A is also necessary for breast cancer stem cell (BCSCs) maintenance, and the results were published online in J Cell Physiol.
silence KDM7A can significantly reduce the number of BCSCs and the formation of in vitro mammary spheres, and inhibit the growth of breast tumors in the body.
restore the expression of KDM7A can save stem cell maintenance defects.
mechanism showed that KDM7A raised stem cell-related factors KLF4 and c-MYC to maintain BCSCs.
addition, KDM7A's knock-out promotes apoptosis by reducing the expression of BCL2 in breast cancer (BrCa) and the phosphation of BAD.
addition, restoring the expression of KDM7A and BCL2 can save breast cancer apoptosis inhibition, indicating that KDM7A inhibited breast cancer apoptosis by raising the level of BCL2 in breast cancer.
, the results show that KDM7A promotes the maintenance and apoptosis inhibition of cancer stem cells in breast cancer.
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