J Clin Gastroenterol: Multiple probiotic strains do not prevent antibiotic-related diarrhea in hospitalized patients

Antibiotic-related diarrhea (AAD) is a common complication in antibiotic therapy, and disorders of the gut microbiome are a potential cause of AAD.
, re-gathering mucous membranes and restoring the balance of the gastrointestinal microbiome may help reduce AAD.
changes in the microbiome of admitted patients show that it is convenient to provide repair to complex intestinal ecosystems using high-dose and multi-bacterial lactic acid bacteria and Bifidobacteria preparations.
, the role of probiotics in preventing AAD in hospitalized adults remains unclear.
, a randomized, double-blind, placebo-controlled clinical trial published in J Clin Gastroenterol showed that multiple probiotic strains did not prevent AAD in hospitalized patients.
study included 314 patients, with an average age of 76, who were randomly grouped (2:2:1) who received 200 mL of placebo yogurt per day, 200 mL probiotic yogurt, or did not drink yogurt (no blind control).
follow-up of patients for 1 month to determine the occurrence of diarrhoea.
results showed that the diarrhea rate in the probiotic group was 23.0%, compared with 17.6% in the placebo group, and the absolute risk was reduced by -5.35% (95% confidence interval, -15.4% to 4.7% ;P to 0.30).
rates were similar in patients in the non-blind control group and the blind method study group (20.9% to 20.2% ;P to 0.91, respectively).
the duration of diarrhoea, maximum number of detops, or extended hospitalization due to diarrhoea between groups.
there was no difference in mortality across the groups.
, the results showed that the combined probiotic strains of LA-5, BB-12 and LC-01 had no effect on the prevention of AAD in hospitalized patients.