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    Home > Active Ingredient News > Antitumor Therapy > J Clin Oncol: Bentuximab vedodin can significantly reduce the radiation dose of children with high-risk Hodgkin's lymphoma without affecting the efficacy

    J Clin Oncol: Bentuximab vedodin can significantly reduce the radiation dose of children with high-risk Hodgkin's lymphoma without affecting the efficacy

    • Last Update: 2021-05-08
    • Source: Internet
    • Author: User
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    Bentuximab vitoxin is an effective anti-CD30 antibody drug conjugate, which has been approved for the treatment of adult classic Hodgkin's lymphoma (HL).


    Lymphoma in children

    This open-label, single-arm, multi-center trial included patients (age ≤ 18 years) with stage IIB, IIIB, or IV classic HL.


     

    Of the 77 patients who participated in the study, 27 (35%) achieved complete remission at ERA and did not receive radiation therapy.


    In summary, the results of the study show that the integration of Bentuximab Vidotin into the first-line treatment of children with high-risk HL is highly tolerated by the children, which is conducive to significantly reducing the dose of radiotherapy and can be achieved Good curative effect.


     

    Original source:

     

    Monika L Metzger, et al.


    ncbi.
    nlm.
    nih.
    gov/33826362/" target="_blank" rel="noopener">Excellent Outcome for Pediatric Patients With High- Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation in this message
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