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A phase 3 randomized trial, cervical cancer postoperative radiotherapy (PARCER), compared image-guided modulated radiotherapy (IG-IMRT) with three-dimensional conformal radiotherapy (3D-CRT) for advanced cervical cancer patients receiving postoperative radiotherapy Toxicity
Late Toxicity After Adjuvant Conventional Radiation Versus Image-Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled Trial
Late Toxicity After Adjuvant Conventional Radiation Versus Image-Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled TrialIn this trial, the test patients were randomly assigned to the IG-IMRT group or the 3D-CRT group, and stratified according to the type of hysterectomy and the use of concurrent chemotherapy
A: Cumulative incidence of ≥grade 2 late GI toxicity; B: Cumulative incidence of ≥grade 3 late GI toxicity
A: Cumulative incidence of ≥grade 2 late GI toxicity; B: Cumulative incidence of ≥grade 3 late GI toxicityFrom 2011 to 2019, a total of 300 patients were randomly divided into two groups: 151 in the IG-IMRT group and 149 in the 3D-CRT group
After a median follow-up of 46 months (interquartile range 20-72), the 3-year cumulative incidence of GI toxicity ≥ 2 in the IG-IMRT group and 3D-CRT group was 21.
A: The pelvic recurrence-free survival rate of the two groups; B: the disease-free survival rate of the two groups
A: The pelvic recurrence-free survival rate of the two groups; B: the disease-free survival rate of the two groupsHowever, there was no significant difference in treatment prognosis between the two groups
There is no significant difference in the prognosis of treatment between the two groups.
For patients who need radiotherapy after cervical cancer surgery, compared with three-dimensional conformal radiotherapy (3D-CRT), image-guided modulated radiotherapy (IG-IMRT) has fewer side effects and does not weaken the curative effect .
Original source:
Supriya Chopra, et al.
Late Toxicity After Adjuvant Conventional Radiation Versus Image -Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled Trial
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