J Clin Oncol: Replacing CT with MRI and lengthening the follow-up interval have no adverse effect on long-term outcomes in patients with stage I seminoma

Clinically, about half of testicular tumors are seminoma
.
The survival rate after orchiectomy for stage I seminoma is almost 100%

The TRISST trial was a noninferiority, phase 3 factorial trial designed to assess whether the use of magnetic resonance imaging (MRI) or reduced frequency of scans did not increase the rate of late recurrence

6-year late recurrence rate on MRI vs CT scan

Between 2008 and 2014, a total of 669 patients were recruited, the mean tumor size was 2.
9 cm, and 358 (54%) were low-risk (<4 cm, without rete testis involvement)
.
After a median follow-up of 72 months, 82 (12%) patients relapsed

6-year late recurrence rate with 3 vs 7 scans

In addition, the analysis showed that MRI was not inferior to CT ; MRI detected fewer recurrences (2 [0.

Original source:

Johnathan K.
Joffe, et al.
Imaging Modality and Frequency in Surveillance of Stage I Seminoma Testicular Cancer: Results From a Randomized, Phase III, Noninferiority Trial (TRISST).