J Crohns Colitis: Characteristics and clinical prognosis of patients with perianal fistula-related cancer in Crohn's disease

Perianal fistula is a characteristic complication of Crohn's disease (CD) patients .

Perianal fistula is a characteristic complication of Crohn’s disease (CD) patients.

Perianal fistula-related cancer is an under-researched risk faced by CD patients.

diagnosis

This is a retrospective case-control study conducted in four German hospitals.

The overall survival rate of patients stratified according to histological type, lymph node metastasis, distant metastasis, and surgical margins

The overall survival rate of patients stratified according to histological type, lymph node metastasis, distant metastasis, and surgical margins

Among 40 patients with malignant tumors, 33 cases were adenocarcinoma and 7 cases were squamous cell carcinoma.

Compared with patients with cancer-free perianal fistula CD, patients with fistula-related malignancies were younger when they were diagnosed with Crohn's disease.

Progression-free survival of patients stratified according to histological type, lymph node metastasis, distant metastasis, and surgical margins

Progression-free survival of patients stratified according to histological type, lymph node metastasis, distant metastasis, and surgical margins

There were significant differences in fistula-related findings between the two groups.

Complex and severe fistula signs, including complex anatomy and chronic activity, are significantly more common in patients with fistula-related malignancies.

In patients with adenocarcinoma or squamous cell carcinoma with Crohn’s disease and perianal fistula, the characteristics of the fistula determine the risk of malignancy.

Original source:

Palmieri Chiara, Müller Gerhard, Kroesen Anton J et al.

org/10.
1093/ecco-jcc/jjab05" target="_blank" rel="noopener">Perianal fistula-associated carcinoma in Crohn's disease: a multicenter retrospective case control study in this message