J Cutan Med Surg: Vaccination guidelines for immunosuppressive patients with immunosuppressive diseases
Last Update: 2020-06-16
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Patients with immunosuppressive diseases have more infectious episodes than healthy people, but the vaccination practices of doctors for this group of patients are still not satisfactoryThe purpose of this study is to assess the safety and efficacy of vaccines in individuals exposed to immunosuppressive therapy and to provide evidence-based clinical practice recommendationsThe researchers conducted a literature search on the safety and efficacy of vaccination in immunosuppressive therapy patients (2009-2017)Use recommended, evaluated, developed, and evaluated systems to grade the resultsThe results showed that several immunosuppressive therapies weakened the vaccine responseTherefore, vaccination should be provided before treatment, as long as practicableInactivated vaccines can be inoculated without interruption of treatmentSimilarly, there is evidence that the live shingles vaccine is safe and effective when receiving selective immunosuppressive therapy, although the use of subunit vaccines is preferredCaution should be exercised against other live vaccinesDrug pharmacokinetics, vaccine-induced viral emisiis duration and immune response dynamics should be considered to determine the appropriate timing for vaccination and treatment (re) to beginInfants exposed to immunosuppressive therapy through breast milk are usually immunized according to local guidelinesIntrauterine exposure to immunosuppressants is not a contraindication of inactivated vaccinesLive vaccines for detoxification in infants and children for 12 months, including measles, mumps, rubella and chickenpox, are safe to be vaccinated because the time is sufficient for the drug to be removedIn summary, the results suggest that immunosuppressants may weaken the vaccine's response, but the protective benefits are generally maintainedWhile these recommendations are evidence-based, they are not a substitute for clinical judgement, and decisions on vaccination must carefully assess risks, benefits and individual patients
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