J Exp Med: The relationship between lipid metabolism and tumor development

Tumor has become the primary killer of human health, and the research on tumor metabolism will provide a new target for tumor treatment.
On December 19, 2020, a team of professors from Zhejiang University's Institute of Translational Medicine (Professor Lu Zhimin was a distinguished tenured professor at the M.D. Anderson Cancer Center at the University of Texas and a recipient of the Research Achievement Award) published a lengthy summary paper entitled: Lipid metabolism and cancer in the Journal of Student Medical.
The paper summarizes the research progress of tumor cell lipid metabolism regulation and introduces the new methods of tumor treatment which have been clinically used to interfere with lipid metabolism, and discusses and analyzes the future development trend of the field based on the existing research results.
lipids, as well as proteins and nucleic acids, are important components of the biofilms and structural units that make up cells.
addition, lipids are used for energy storage and metabolism and play an important signaling molecular role in a variety of cellular activities.
of lipid metabolism, such as lipid ingestion, synthesis and hydrolysing, are essential for maintaining cell stability.
the progression of tumors, the availability of nutrients in the tumor microencology is constantly changing, so tumor cells use lipid metabolism to maintain their rapid proliferation, survival, migration, invasion and metastasis.
one of the leading scholars in the field of metabolic research, Professor Lu Zhimin has made pioneering and systematic achievements in the study of energy metabolism of tumor cells.
Lu Zhimin's team's work on Nature in early 2020 (see BioArt report: Nature , Lu Zhimin/Hong Mingqi collaboration to reveal tumor cell-specific lipid anabolic mechanisms) reveals tumor cell-specific lipid anabolic anabolic mechanisms, and for the first time discovers the glyco-isomerase P CK1 has protein kinase activity, which reveals that PCK1 phosphates endosometial protein INSIG1/2 with GTP as a phosphoric acid-based feeder, which makes its binding to intracellular lipids appear a barrier, which in turn promotes the activation of SREBP signaling path path and lipid synthesis of tumor cells.
this is different from previous protein kinases that use ATP as a phosphate-based feed.
also discusses that PCK1 endosurgen network potential is an important molecular mechanism for tumor cells to co-regulate glycosin reduction and lipid synthesis activation, which reveals the abnormality of tumor cell lipid induction and the important mechanism of lipid synthesis continuous activation.
And in this review paper, Professor Lu Zhimin systematically summarizes and discusses the research progress related to lipid (fatty acid and cholesterol) intake, fat production and FAO-dependent lipid solution in tumor cells, and introduces in detail the transcriptional regulation of fat production in tumor cells.
, Professor Lu Zhimin also discusses different methods for cancer treatment by destroying lipid metabolism.
the molecular regulatory network of tumor lipid anabolism (from review)