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Patients with background loss-of-compensation cirrhosis combined with stubborn ascites or thoracic fluid had poor prognosis.
tovaputan has been used to treat sodium water storage associated with cirrhosis.
, however, relapses of asymploda have been observed in some cases, despite short-term reactions.
study aims to explore the relationship between relapse rate of ascer abdominal water and long-term recurrence-free response and prognosmation.
method researchers retrospectively analyzed 100 patients with non-compensation cirrhosis treated with tovaputan.
the recurrence rate against the standards of the EASL Clinical Practice Guidelines.
the recurrence rate and prognostication of non-reactive, relapsed patients and long-term responders.
also assessed baseline factors associated with short-term reactions, relapses and long-term reactions, and concluded with statistical analysis.
results showed that about 31.0% of patients with disproparated cirrhosis relapsed after short-term remission.
although there was no significant difference in the prognosmation of short-term reactions (p s 0.07), the prognosmation of long-term responders was significantly better than that of relapses and non-reactive persons (p slt;0.01).
low CRP levels and high urine Na/K ratio are important factors associated with short-term reactions, while the presence of acute kidney injury is also associated with non-reactive factors.
CRP levels are low (recurrence: .lt;1.10 mg / dl, long-term response: .lt;0.94 mg / dl) are identified as factors associated with recurrence and long-term response.
long-term responders who concluded no recurrence had significantly improved prognosmation.
CRP is a useful predictive indicator of long-term reactions, while renal function parameters are a useful predictive indicator of short-term reactions.
control may be important for long-term response and prognosis in patients with cirrhosis.
Masato Nakai. Et al. Reed response without resynation to Tolvaptan improves long-term survival. J Gastroenterology.2020.Source:MedSci Originals !-- Content Presentation Ends -- !-- Whether login ends.