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Previous studies have shown that there is a clear correlation between the digestive tract and the respiratory microbiome, and that this correlation is more complex than previously thought.
gastric drain delay was associated with an increase in the rejection of grafts, however, the mechanism of this association is not yet clear.
study aims to study the relationship between gastrointestinal dysfunction and micro-biodiversity and composition in the stomach, mouth, and lungs of children with lung transplant recipients.
the study, a forward-looking study, recruited 23 children with lung transplants and 98 children with respiratory symptoms who underwent joint endoscopy and bronchoscopy, respectively.
16S sequencing by collecting samples of stomach, pharynx, and bronchopulmonary bubble sequencing.
sample also used a liquid chromatography to analyze bile composition.
gastric emptying delay is defined as abnormal gastric emptying or elevated stomach bile concentration in the nucleotin visible.
the diversity of each sample bacteria in children with lung transplantation decreased significantly compared to those in children with α respiratory symptoms, the diversity of stomach and pharynx in children receiving lung transplants was significantly reduced.
decrease α this diversity is particularly pronounced in stomach samples of children with delayed gastric drain.
PPI use reduced bacterial diversity Although monoclonal cells were found in the lungs of transplanted children, these microorganisms differed from those found in the stomach;
other factors α reduced diversity of the disease, especially in stomach and pharynx samples, are antibiotics used in the same time as proton pump inhibitors (PPI).
study showed that lung transplant recipients had lower levels of micro-biodiversity in their stomach fluids and pharynx than children with respiratory symptoms who did not receive a lung transplant.
of microbial diversity α in the stomach fluid may be associated with gastric movement disorders.