J Hepatol: Abnormal levels of AST and D-Bil are independent predictive factors for the risk of death in patients with neo-coronary pneumonia

The evolution and clinical significance of hepatic bio-abnormalities in patients with neo-crown pneumonia, as well as the effects of hepatitis B infection on the prognosis of neo-crown pneumonia patients, are not clear.
study aims to explore these issues.
this study carried out a retrospective analysis of 2,073 patients with neo-coronary pneumonia diagnosed in Wuhan, collected the liver function examination carried out vertically in patients, and determined their related factors and death risk through multiple regression analysis.
predicted the survival prognostics of patients with neo-coronary pneumonia using a prognostic nomogram.
the liver abnormal characteristics and re-return of patients with combined hepatitis B and new coronary pneumonia who did not combine hepatitis B.
of 2073 patients, 1,282 (61.8%) had liver bio-chemical abnormalities during hospitalization and 297 (14.3%) had liver damage.
the average AST and D-Bil of patients who died were elevated early after symptoms appeared, and varied from patients who were discharged successfully throughout the clinical process.
AST and D-Bil levels at the time of hospitalization were independent risk factors for death from neocyctic pneumonia (correction risk ratios of 1.39 and 1.66, respectively).
based on the multivariable analysis results, nomodal graph is established, which shows sufficient judgment ability, and the consistency between the prediction results and the observed results is high.
addition, HBV infection does not increase the risk of adverse prognosis associated with neo-coronary pneumonia.
, abnormal levels of AST and D-Bil at the time of hospitalization were independent predictive factors for neo-coronary pneumonia-related mortality.
, liver bio-chemical monitoring, especially at the AST and D-Bil levels, is essential for patients with new coronary pneumonia hospitalized.