J HEPATOL: Don't miss the diagnosis, patients with fatty liver may not have metabolic syndrome!

Non-alcoholic fatty liver is the most common type of fatty liver in China, and it has replaced hepatitis B as the largest chronic liver disease in China

However, it seems that this new definition is not comprehensive enough.

The Liver Research Center of the First Affiliated Hospital of Fujian Medical University found that patients with hepatic steatosis do not have metabolic risks and do not meet the diagnostic criteria of MAFLD, but they still suffer from liver damage and liver fibrosis

Research methods

Research methods

The research center uses the National Health and Nutrition Survey (NHANES III) database

Table 1: Comparison of non-MR-MAFLD and MAFLD

result

result

Although the metabolism-related parameters of non-MR-MAFLD patients are significantly lower, the liver enzyme levels are comparable to those of MAFLD patients

The above results indicate that those patients with severe hepatic steatosis who cannot be diagnosed as MAFLD also have necrotizing inflammatory activity

in conclusion

in conclusion

In general, although patients with severe hepatic steatosis do not have metabolic syndrome and cannot be diagnosed as MAFLD, they still have severe liver damage and fibrosis, and more clinical attention should be given

In general, although patients with severe hepatic steatosis do not have metabolic syndrome and cannot be diagnosed as MAFLD, they still have severe liver damage and liver fibrosis, and more clinical attention should be given

Huang J, Kumar R, Wang M, Zhu Y, Lin S.

Huang J, Kumar R, Wang M, Zhu Y, Lin S.
MAFLD criteria overlooks a number of patients with severe steatosis: Is it clinically relevant? J Hepatol.
2020 Nov;73(5):1265-1267.
doi: 10.
1016/ j.
jhep.
2020.
06.
016.
Epub 2020 Aug 17.
PMID: 32819754.


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