J HEPATOL: Mothers are obese, and offspring are more likely to suffer from fatty liver

Changes in food quality and sedentary life>
.

More than half of Chinese adults are overweight or obese.

More than half of adults in China are overweight or obese, and the rates of overweight and obesity are 34.

Recently, a study published by Karolinska Institutet and Harvard University in the Journal of Hepatology stated that as the obesity rate of women of childbearing age increases, more and more young people are at risk of fatty liver, non-alcoholic Among the metabolic comorbidities of patients with fatty liver, diabetes and hypertension are more common
.

As the obesity rate of women of childbearing age increases, more and more young people are at risk of fatty liver.
Among the metabolic comorbidities of patients with non-alcoholic fatty liver, diabetes and hypertension are more common
.

As the obesity rate of women of childbearing age increases, more and more young people are at risk of fatty liver.

Hannes Hagström et al, Maternal obesity increases the risk and severity of NAFLD in offspring, Journal of Hepatology (2021).
DOI: 10.
1016/j.
jhep.
2021.
06.
045

Hannes Hagström et al, Maternal obesity increases the risk and severity of NAFLD in offspring, Journal of Hepatology (2021).
DOI: 10.
1016/j.
jhep.
2021.
06.
045

Researchers identified 718 cases of non-alcoholic fatty liver diagnosed as those under the age of 25
.

Of these cases, 530 cases with a date of birth before 1992 were excluded because there is no data on the mother’s BMI

Most cases of non-alcoholic fatty liver were diagnosed after 2010
.

The median age is 12.

Data analysis showed that compared with the control group (8.
4%), mothers of non-alcoholic fatty liver offspring had a higher obesity rate (19.
3%), and the mother’s BMI had a dose-response effect.
Compared with mothers with normal BMI, BMI The risk of NAFLD in the offspring of mothers ≥30 kg/m ² is three times higher (aOR=3.
26)
.

However, this risk was not statistically significant in overweight mothers, nor was statistically significant in underweight mothers (aOR=0.

Compared with the control group (8.

BMI BMI (aOR=3.

Estimated value of non-alcoholic fatty liver in offspring

Estimated value of non-alcoholic fatty liver in offspring

Estimated value of severe non-alcoholic fatty liver

Estimated value of severe non-alcoholic fatty liver

In addition to the mother's BMI, socioeconomic factors in particular are significantly related to the offspring's non-alcoholic fatty liver
.

Compared with women born outside the Nordic countries, women born in Nordic countries have a significantly lower risk of non-alcoholic fatty liver in their offspring (aOR=0.

In general, when mothers have a higher BMI in the early stages of pregnancy, their offspring are at increased risk of non-alcoholic fatty liver
.

The incidence of non-alcoholic fatty liver in children in the United States doubled between the late 1980s and 2010
.
In addition, a second analysis of the Western Australia pregnancy cohort study found that among 1170 17-year-old adolescents, 15.
2% had non-alcoholic fatty liver, and maternal obesity was one of the risk factors for non-alcoholic fatty liver in offspring
.

Socio-economic parameters, such as the birth of immigrant mothers, smoking, and lower education are all risk factors for non-alcoholic fatty liver in offspring.
People with lower education have higher BMI and type 2 diabetes.
These factors are also Will affect the prevalence of non-alcoholic fatty liver
.

Socio-economic parameters, such as the birth of immigrant mothers, smoking, and lower education are all risk factors for non-alcoholic fatty liver in offspring.
People with lower education have higher BMI and type 2 diabetes.
These factors are also Will affect the prevalence of non-alcoholic fatty liver
.
Socio-economic parameters, such as the birth of immigrant mothers, smoking, and lower education are all risk factors for non-alcoholic fatty liver in offspring.
People with lower education have higher BMI and type 2 diabetes.
These factors are also Will affect the prevalence of non-alcoholic fatty liver
.

In the future, the prevalence of non-alcoholic fatty liver disease in children and adolescents will increase, and it is likely to continue into old age
.
Previous studies have shown that high BMI in early life is related to the development of severe liver disease.
These results indicate that obesity may also have adverse consequences at reproductive age.
This further emphasizes that healthy life>
.

In the future, the prevalence of non-alcoholic fatty liver disease in children and adolescents will increase, and it is likely to continue into old age
.
Previous studies have shown that high BMI in early life is related to the development of severe liver disease.
These results indicate that obesity may also have adverse consequences at reproductive age.
This further emphasizes that healthy life>
.
In the future, the prevalence of non-alcoholic fatty liver disease in children and adolescents will increase, and it is likely to continue into old age
.
Previous studies have shown that high BMI in early life is related to the development of severe liver disease.
These results indicate that obesity may also have adverse consequences at reproductive age.
This further emphasizes that healthy life>
.

Original source:

Hannes Hagström et al, Maternal obesity increases the risk and severity of NAFLD in offspring, Journal of Hepatology (2021).
DOI: 10.
1016/j.
jhep.
2021.
06.
045

Hannes Hagström et al, Maternal obesity increases the risk and severity of NAFLD in offspring, Journal of Hepatology (2021) DOI:.
10.
1016 / j.
jhep.
2021.
06.
045 in this message