J Hepatol: Obercholic acid promotes the excretion of liver bile acid in patients with primary bile cirrhosis.

Obe bile acid (OCA) is an an agitant of the nuclear bile acid receptacle FXR, which regulates the metabolism of liver bile acid.
this study tested patients with primary bile cirrhosis (PBC) who did not respond well to the treatment of bear deoxycholic bile acid (UDCA), and it has been clear whether OCA treatment affects liver transport in combination with bile acid.
Kristoffer Kj?rgaard, from the Department of Digestive Internal Care at Ayhus University Hospital, and eight other PBC patients treated with UDCA with an alkaline phosphatase of 1.5 ULN participated in the randomized double-blind control study.
at the same time as UDCA treatment, patients were randomly assigned to two groups (placebo group, combined OCA treatment group) for a 3-month treatment period and no research therapy at intervals of 1 month.
After two treatment cycles, we calculated the rate at which bile acid was transported in the blood, liver cells, bile tubes and bile tube constants, and combined with PET, scanned the liver using the bile acid tracker ( N-methyl-11C) cholylsarcine (11C-CSar) and usedgreen liver blood infusion.
DOI: The results showed that OCA increased blood flow from the liver by 11% (p-0.045), increased the one-way intake clearance rate of 11C-CSar from the blood into liver cells by 11% (p-0.01), and increased the rate of 11C-CSar from liver cells to bile tube secretion by 73% (p-0.03).
this resulted in an reduction in OCA-induced 11C-Csar stay time in liver cells from 11 minutes to 8 minutes in the median group, equivalent to a 30% reduction (p-0.01).
study of PBC patients treated with UDCA showed that OCA increased the transport of bile acid tracer 11C-CSar in combination with placebo, thereby increasing the transport of endogenous binding bile acid from liver cells to bile tubes.
, OCA reduces the time liver cells are exposed to potentially cytotoxic bile acid.
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