J Hepatol: What kind of "sugar" is harmful to health from excessive consumption of sugary drinks?

Excessive intake of fructose can increase new fat production, blood triglycerides and liver insulin resistance .

Excessive intake of fructose can increase new fat production, blood triglycerides and liver insulin resistance

This is a double-blind randomized trial that recruited 94 subjects.

FSR% of each group

FSR% of each group

In subjects who consumed beverages containing free fructose and fructose-glucose (sucrose) every day, the base fraction secretion rate of newly synthesized FA in the liver increased by 2 times compared with the control group (median FSR%/day: sucrose 20.

In subjects who consumed beverages containing free fructose and fructose-glucose (sucrose) every day, the base fraction secretion rate of newly synthesized FA in the liver increased by 2 times compared with the control group (median FSR%/day: sucrose 20.

Oxidation of plasma FFA and total FA after SSB intervention for 5 weeks

Oxidation of plasma FFA and total FA after SSB intervention for 5 weeks

Intake of fructose does not change the basic secretion of newly synthesized VLDL-TAG, in addition, it does not change the decomposition rate of peripheral fat, nor does it change the oxidation rate of total FA and plasma FFA.

Intake of fructose does not change the basic secretion of newly synthesized VLDL-TAG, in addition, it does not change the decomposition rate of peripheral fat, nor does it change the oxidation rate of total FA and plasma FFA.

In the case of a stable calorie intake, frequent consumption of beverages containing fructose and sucrose can increase liver FA synthesis even in the basal state, but this change is not observed after glucose intake.

Original source:

Geidl-Flueck Bettina, Hochuli Michel, Németh ágota et al.

org/10.
1016/j.
jhep.
2021.
02.
027">Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial in this message