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    Home > Active Ingredient News > Digestive System Information > J Hepatology: Elevated bilirubin and alkaline phosphatase are associated with prolonged recovery time from drug-induced liver injury

    J Hepatology: Elevated bilirubin and alkaline phosphatase are associated with prolonged recovery time from drug-induced liver injury

    • Last Update: 2021-06-10
    • Source: Internet
    • Author: User
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           Drug-induced liver injury (DILI) is a side effect after drug use.
    Although most DILI will subside after stopping some drugs, the recovery time varies from patient to patient, and 6-12% of cases will eventually develop into chronic liver disease.
    damage.
    Chronic liver damage can lead to fibrosis and cirrhosis and negatively affect the quality of life.
    Here, this study investigated the clinical factors and drug characteristics of potential risk factors that affect the time course of DILI recovery.

     Drug-induced liver injury (DILI) is a side effect after drug use.
    Although most DILI will subside after stopping some drugs, the recovery time varies from patient to patient, and 6-12% of cases will eventually develop into chronic liver disease.
    damage.

     

          Researchers collected a total of 294 cases.
    Higher serum bilirubin and alkaline phosphatase (ALP) at the onset of DILI, longer onset time, and slower drug metabolism are associated with a longer recovery time from liver injury, and the researchers define it according to the score assigned by the model The high-risk and low-risk groups are selected.
    The estimated probability of recovery from drug-induced liver injury at 6 months in the high-risk group was 0.
    46 (95% CI 0.
    26-0.
    61), and in the low-risk group was 0.
    93 (95% CI 0.
    58-0.
    99).
    The results of this study indicate that the recovery time of DILI is related to the degree of drug metabolism, serum bilirubin and ALP changes at the onset of DILI.

    Figure: Total bilirubin, alkaline phosphatase levels, onset time, and drug metabolism at the onset of DILI are always related to recovery time

    Figure: Total bilirubin, alkaline phosphatase levels, onset time, and drug metabolism at the onset of DILI are always related to recovery time

     

          In this study, researchers confirmed that drug properties and clinical factors are related to the time required to recover from drug-induced liver injury (DILI).
    And the researchers found that the total bilirubin, alkaline phosphatase levels, onset time, and drug metabolism during the onset of DILI are always related to the recovery time.

      In this study, researchers confirmed that drug properties and clinical factors are related to the time required to recover from drug-induced liver injury (DILI).
    And the researchers found that the total bilirubin, alkaline phosphatase levels, onset time, and drug metabolism during the onset of DILI are always related to the recovery time.

     

     

    Original source:

    KristinAshby.
    Et al.
    Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.
    J Hepatology.
    2021.

    Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.


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