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    Home > Active Ingredient News > Digestive System Information > J Hepatology: β-term hemodynamic effects of the adhesive blocker can have a negative effect on the survival of patients with disproparated cirrhosis.

    J Hepatology: β-term hemodynamic effects of the adhesive blocker can have a negative effect on the survival of patients with disproparated cirrhosis.

    • Last Update: 2020-10-12
    • Source: Internet
    • Author: User
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    The most serious result of loss of compensation for cirrhosis can lead to death, and prevention of death can be regarded as the main goal of patients with loss of compensation for cirrhosis.
    non-selective β (NSBBs) are effective in preventing varicose rupture bleeding and reducing mortality.
    , it β whether the effects of blockers on arterial pressure and/or heart function can counteract the benefits of reducing valve pressure in late-stage cirrhosis is debatable.
    , this study aims to assess the β effects of β-blockers on survival in patients with loss of compensation for cirrhosis and changes in the systemic hemodynamics.
    researchers included patients with cirrhosis and high-risk esotheria varicose veins in the study, grouping them according to the presence or absence of compensation (abdominal water with or without significant encephalopathy).
    The effect of β blockers on survival in patients with hysteresis of cirrhosis was statistically analyzed before the use of β blockers was started and again 1 to 3 months after treatment β

    study included 403 patients (190 out of compensation and 213 out of compensation).
    patients with β of the same blocker reduced intravenous pressure (10±18% VS 15±12% ;p slt; 0.05), with a greater reduction in heart rate and CO (p .lt; 0.001) (17±15% VS 10±21% ;p slt; 0.01).
    in patients with insanity cirrhosis, the decrease in CO was greater than that of survivors β (21±14% VS 15±16%; 0.05) and CO under β-subject blockers independently predict death through competitive risk regression analysis with good diagnostic accuracy (C index 0.74; 95% CI 0.66-0.83).
    patients with ≥ CO≤≥5L/min had a higher risk of death (risk ratio 0.44; 95% CI 0.25-0.77; p s 0.004) compared to CO≥5L/min.
    in patients with high-risk varicose veins and disproflated cirrhosis, β-blockers responded more to the systemic hemodynamics and had smaller venous pressure drops.
    β effects of adhesive blockers on CO may adversely affect the survival of patients with reparational cirrhosis.
    .
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