J Immunother Cancer: The dynamic changes of tumor-infiltrating immune cells can predict the patient's response to neoadjuvant chemotherapy

Triple negative breast cancer (TNBC) is a heterogeneous tumor with a poor prognosis.

Breast cancer.

This study performed immunohistochemical analysis of matched tumor biopsy samples from 66 TNBC patients from the WSG-ADAPT-TN trial at baseline and 3 weeks after NACT treatment.

The levels of CD4, CD8, CD73, T cells, PD1-positive CD4 and CD8 cells and PDL1 in the stroma and/or tumor at baseline and at the 3rd week were assessed, and the correlation between changes in these indicators and pCR

Note: "cold": lack of immune cell infiltration; "hot" tumor cells are in contact with immune cells.

PD1-positive CD4 and PD1-positive CD8 cells infiltrate tumors with a higher pCR rate after the transition from "cold" to "hot" PD1-positive CD8 cells are converted from "hot" to "cold" pCR T cells and PD1-positive CD4 are not observed The pCR rate of tumors whose cell infiltration changes from "hot" to "cold" is significantly reduced

In conclusion, this exploratory study suggests that the comprehensive analysis of early immune cell infiltration dynamics supplements the predictive markers of pCR and is expected to improve the adjustment of personalized treatment strategies for TNBC patients .

The comprehensive analysis of early immune cell infiltration kinetics supplements the predictive markers of pCR, which is expected to improve the adjustment of personalized treatment strategies for TNBC patients

Original source:

Original source:

Graeser M, Feuerhake F, Gluz O, et al bmj.

bmj.
com/content/9/5/e002198" target="_blank" rel="noopener">Immune cell composition and functional marker dynamics from multiplexed immunohistochemistry to predict response to neoadjuvant chemotherapy in the WSG-ADAPT-TN trial

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