J Infect Chemother: Epidemiological and risk factors for CRE-induced neurosurgery bacterial meningitis/encephalitis

The purpose of this retrospective study is to identify the epidemiological characteristics of meningitis/encephalitis associated with CRE and to clarify the risk factors for CRE neurosurgery infection, the results of which were published online in J Infect Chemother.
researchers reviewed each patient's medical records, extracted 20 clinical variables on risk factors, and evaluated CRE-meningitis/encephalitis using multivariable logistic analysis.
results show that in 2012-2017, the positive rate for neurosurgery meningitis/encephalitis was 7.9% (2947/29605) and E. coli accounted for 6.3% (185/2947) of all bacterial infections.
133 E. coli strains in this study included 26 CRE isolated strains.
, a single-variable analysis showed that the risk factors for CRE meningitis were ventilators, bacteremia, hospitalization in the intensive care unit (ICU), hospital-based pneumonia, and death from infection.
multivariative analysis shows that hospital-based pneumonia and infection-caused deaths are independent risk factors for CRE meningitis.
, the results show that CRE is one of the most drug-resistant bacteria published by the World Health Organization (WHO) in 2016, and that meningitis/encephalitis caused by CRE is an important sign of the failure of neurosurgery and requires immediate attention from doctors.
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