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    Home > Active Ingredient News > Infection > J Int AIDS Soc: Estimates of Population-Level HIV-1 Incidence by Cross-sectional Incidence Analysis in the HPTN 071 (PopART) Trial

    J Int AIDS Soc: Estimates of Population-Level HIV-1 Incidence by Cross-sectional Incidence Analysis in the HPTN 071 (PopART) Trial

    • Last Update: 2022-01-22
    • Source: Internet
    • Author: User
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    Background: HIV incidence is the rate of new HIV infections in a population and is the primary measure for assessing the status of the epidemic and the effectiveness of preventive interventions
    .


    Cross-sectional incidence analysis used experimental algorithms (MAAs) to estimate HIV incidence


    This method is simpler and less expensive than estimating incidence using longitudinal cohort studies


    Results: The study included 15,845 people who were HIV-negative, 4406 people who were HIV-positive at both visits, and 221 people who seroconverted between visits
    .


    Viral load (VL) data were available for all HIV-positive participants at the two-year visit


    Figure 1 Comparison of cross-sectional incidence estimates to observed incidence in HPTN 071 (PopART)
    .


    This figure shows the comparison of annual HIV incidence rates observed in the HPTN 071 (PopART) trial with incidence rates estimated with three multiple analysis algorithms (MAAS)


    Figure 1 Comparison of cross-sectional incidence estimates to observed incidence in HPTN 071 (PopART)


    Figure 2 Comparison of cross-sectional estimated and observed incidence of HPTN 071 (PopART) in young adults, by institution, country, sex, and sex
    .


    The figure shows the observed incidence and incidence estimates for the three multiple-trial algorithms (MAAs)


    Figure 2 Comparison of cross-sectional estimated and observed incidence of HPTN 071 (PopART) in young adults, by institution, country, sex, and sex


    MAA-C and LAG+VL MAA provided accurate point estimates of incidence in cohorts with higher levels of viral suppression


     Klock E, Wilson E, Fernandez RE, et al.


    Validation of population-level HIV-1 incidence estimation by cross-sectional incidence assays in the HPTN 071 (PopART) trialLeave a comment here
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