J Int Med Res: Thyroid hormones and depression are closely related to obesity.

In this study, we investigated the prevalence of thyroid dysfuncy and depression in centrally obese participants, and analyzed the relationship between thyroid hormones and depression and central obesity participants.
randomly selected 858 central obesity participants and 500 non-obese controls.
For all participants, we measured serum free triiodine thyroxine (FT3), free thyroxine (FT4), thyroid stimulant (TSH), body mass index (BMI), waist-to-hip ratio (WHR), short-bed blood sugar and insulin, insulin resistance, steady-state model assessment (HOMA-IR), lipid concentration, and blood pressure.
used the Epidemiological Research Center-Depression (CES-D) scale to assess depression.
results showed that participants with central obesity had a higher risk of hypothyroid and depression than non-obese control groups.
serum FT4 levels were negatively associated with BMI and serum TSH levels, and positively associated with BMI, WHR, total triglycerides (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C).
excluding participants with hypothyroidism and hyperthyroidism, serum FT4 levels in the remaining central obese participants were negatively associated with BMI and serum TSH levels were positively associated with BMI.
CES-D score was positively related to BMI.
, the study found a high prevalence of hypothyroid and depression among centrally obese participants.
FT4 and TSH are important for weight regulation.
is positively associated with obesity.
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