J INTERN MED: LDL-cholesterol levels are a risk factor for retinal and kidney disease in children and adults with type 1 diabetes

Microvascular complications are common in diabetic patients, and poor blood sugar control is a major factor.
a recent study published in Journal of Internal Medicine, an authoritative journal in the field of internal medicine, explores the relationship between elevated LDL-cholesterol levels and the risk of retinal lesions or kidney disease in younger patients with type 1 diabetes.
this is a national population-based observational queue study that includes all children and adults with type 1 diabetes registered with the Swedish National Diabetes Registry for ≤10 years between 1998 and 2017.
researchers calculated a rough rate of occurrence with a 95% confidence interval (CI) and used multivariable Cox regression to estimate the rough and adjusted risk ratio of retinal or kidney disease in the four LDL-cholesterol groups (HRs): .lt;2.6 (reference group), 2.6-3.4, 3.4-4.1, and .gt;4.1 mmol/L.
From diagnosis to the end of the study, the researchers followed a total of 11024/12350 (retinal lesions/kidney disease, two queues, two queues) in children and adults (with a medium age of 21 years and 42% of women).
the median course of diabetes entering the study were in the retinal and kidney disease queues for 6 and 7 years, respectively.
LDL-cholesterol median is 2.4mmol/L and the median HbA1c is 61 mmol/mol (7.7%).
adjusted for multiple variables, HRs (95%CI) of individual retinal lesions with LDL-cholesterol levels of 2.6-3.4, 3.4-4.1, or 4.1 mmol/L were 1.13 (1.03-1.23), 1.16 (1.02-1.32) and 1.18 (0.99-1.41), compared to the reference group.
corresponding HRs for kidney disease are 1.15 (0.96-1.32), 1.30 (1.03-1.65) and 1.41 (1.06-1.89).
this, it was noted that young people with type 1 diabetes with high LDL-cholesterol levels had an increased risk of retinal and kidney disease, independent of blood sugar and other identified risk factors for vascular complications.
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