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Recently, an authoritative journal in the field of internal medicine published a research article in the Journal of Internal Medicine.
Osteoporosis
The researchers conducted a comparative study of the effectiveness of a cohort study design based on a national population
According to the patient's subsequent medication mode, patients are divided into continuous or non-continuous denosumab or bisphosphonate users
Compared with those who continued to use denosumab, non-sustained denosumab users had severe osteoporotic fractures (hazard ratio (HR)=1.
It can be seen that discontinuation of denosumab will lead to an increased risk of osteoporotic fractures, especially vertebral fractures, and the increased risk often manifests within one year after stopping the drug
Discontinuation of denosumab will lead to an increased risk of osteoporotic fractures, especially vertebral fractures, and the increased risk often manifests within one year after stopping the drug
Original source:
Shau-Huai Fu.
Increased fracture risk after discontinuation of anti- osteoporosis medications among hip fracture patients: a population-based cohort study
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