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    Home > Active Ingredient News > Endocrine System > J INTERN MED: Relationship between mitochondrial DNA copy number and metabolic syndrome and type 2 diabetes

    J INTERN MED: Relationship between mitochondrial DNA copy number and metabolic syndrome and type 2 diabetes

    • Last Update: 2021-02-01
    • Source: Internet
    • Author: User
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    Mitochondrials play an important role in cell metabolism, and dysfunction is thought to be associated with metabolic disorders.
    multiple copies of mitochondrial DNA in each cell.
    quantitative analysis of the number of copies of mitochondrial DNA (mtDNA-CN) can be used to assess mitochondrial dysfunction.
    , researchers looked at the cross-sectional link between mtDNA-CN and type 2 diabetes, as well as the potential mediated role of metabolic syndrome, in a recent study published in Journal of Internal Medicine, an authoritative journal in the field of internal medicine.
    researchers evaluated 4,812 patients from the German Chronic Kidney Disease (GCKD) study and 9,364 patients from the South Tyrol Cooperative Health Study (CHRIS).
    researchers measured MtDNA-CN in whole blood using a proton-based standardized qPCR.
    two studies, there was a significant correlation between mtDNA-CN and most metabolic syndrome parameters: mtDNA-CN decreased with the increase in the number of metabolic syndrome components.
    addition, in models that were adjusted for age, sex, smoking and kidney function, individuals with lower mtDNA-CN developed metabolic syndrome (mtDNA-CN decreased by 10 ORs to 1.025; 95% CI is 1.011-1.039, p=3.19×10-4) and type 2 diabetes (OR=1.027; 95% CI is 1.012-1.041; The odds of p-2.84 ×10-4) are significantly higher.
    -mediated analysis showed that in GCKD studies, the correlation between mtDNA-CN and type 2 diabetes was mainly mediated by waist circumference (66%), and in CHRIS studies it was mainly mediated by multiple metabolic syndrome parameters, especially body mass index and triglycerides (41%), which showed that mtDNA-CN was negatively associated with a higher risk of metabolic syndrome and type 2 diabetes.
    effects of mtDNA-CN on people with type 2 diabetes are mostly driven by obesity.
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