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J INTERN MED: Risk of primary liver cancer in patients with acute hepatic porphyria

 Last Update: 2022-03-03
 Source: Internet
 Author: User

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Acute hepatic porphyria is associated with the risk of primary liver cancer, but risk estimates have not been established, nor are the characteristics of acute hepatic porphyria that predict the risk of primary liver cancer
.

In this registry-based, matched cohort study, researchers assessed associations with biochemical and clinical porphyria severity, genotype, age, and gender, according to a study published in the Journal of Internal Medicine.
risk of primary liver cancer
.

We included all patients with acute intermittent porphyria (AIP), variegated porphyria (VP), or hereditary coproporphyria (HCP) in the Swedish Porphyria Registry between 1987 and 2015
.

This acute hepatic porphyria cohort was compared with age, sex, and county-matched reference individuals from the general population

We identified 1244 patients with acute hepatic porphyria (1063 [85%] AIP patients)
.

During a median follow-up of 19.

This study confirmed a higher risk of primary liver cancer and identified a strong association with clinical and biochemical AIP activity

Original source:

Mattias Lissing, et al.
Risk of primary liver cancer in acute hepatic porphyria patients: A matched cohort study of 1,244 individuals
.

Journal of Internal Medicine.

Risk of primary liver cancer in acute hepatic porphyria patients: A matched cohort study of 1,244 individualsLeave a comment here

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