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Research evidence shows that the differentiation and function of immune cells are affected by cell metabolism, and vice versa , which is a prerequisite for immune response.
Immune differentiation and function of cells of the affected cell metabolism, and vice versa immune differentiation, and function of cells of the affected cell metabolism, and vice versaimmunization
Acquired bullous pemphigoid epidermolysis (EBA) is an autoantibody-driven, granulocyte-mediated skin disease.
Acquired bullous pemphigoid epidermolysis (EBA) is an autoantibody-driven, granulocyte-mediated skin disease.
Paul et al.
Metformin
Metformin and 2-deoxyglucose can reduce BP-like EBA
Metformin and 2-deoxyglucose can reduce BP-like EBABoth metformin and 2-deoxyglucose can reduce the severity of the BP-like EBA antibody transfer model.
Both metformin and 2-deoxyglucose can reduce the severity of the BP-like EBA antibody transfer model.
The neutrophil response triggered by IC requires the participation of aerobic glycolysis and OxPhos
The neutrophil response triggered by IC requires the participation of aerobic glycolysis and OxPhosBy reducing OxPhos, metformin can also inhibit this neutrophil response, but only when overdose does it have this effect, which makes it unlikely that metformin will have a direct effect on neutrophils in the body.
All in all, the results of the study emphasized that neutrophil glycolysis and OxPhos are potential targets for the treatment of EBA, and 2-deoxyglucose and metformin are potential drugs.
The results of this study emphasize that glycolysis of neutrophils and OxPhos are potential targets for the treatment of EBA, and 2-deoxyglucose and metformin are potential drugs.
Original source:
Schilf Paul, Schmitz Marie, Derenda-Hell Aleksandra et al.
org/10.
1016/j.
jid.
2021.
01.
014">Inhibition of glucose metabolism abrogates the effector phase of bullous pemphigoid-like epidermolysis bullosa acquisita in this message