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    Home > Biochemistry News > Natural Products News > J Lipid Res: Drinking orange juice may help prevent fat.

    J Lipid Res: Drinking orange juice may help prevent fat.

    • Last Update: 2020-10-03
    • Source: Internet
    • Author: User
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    March 11, 2020 / / -- Drinking two and a half cups of orange juice a day can reverse obesity and reduce the risk of heart disease and diabetes -- a benefit Western researchers attribute to nobiletin, a molecule found in sweet oranges and oranges.
    , led by the Shulik School of Medicine and the School of Dentists, showed that mice who ate both high-fat, high-cholesterol foods and nobiletin were significantly thinner and had lower insulin resistance and lipid levels than mice that ate only high-fat, high-cholesterol foods.
    photo source: The study, "The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK," was recently published in Journal of Lipid Research.
    "We continue to demonstrate that we can also use Nobiletin to intervene," said Murray Huff, a professor at Shulik University who has studied the role of Nobiletin for more than a decade.
    "We have shown that in mice that have already experienced all the negative symptoms of obesity, we can use nobiletin to reverse these symptoms and even begin to reverse the plaques that accumulate in the arteries, namely atherosclerosis.
    " but Huff said he and his team at the Robarts Institute still can't pinpoint exactly how Nobiletin works.
    speculated that the molecule may act as a path to regulate the way body fat is processed.
    this regulatory factor, called AMP kinase, "turns on" the mechanism by which fat is burned in the body to produce energy, while also preventing fat production.
    , however, when researchers studied the effects of nobiletin on genetically modified deAMP kinase mice, the results were the same.
    : "This result tells us that Nobiletin does not act on AMP kinases, but bypasses the main regulatory factors used by fat in the body.
    it's still a question for us - how did Nobiletin do it? Huff said that while the mystery remains, the latest results are still clinically important because they show that nobiletin does not interfere with other drugs that act on the AMP kinase system.
    that current treatments for diabetes, such as metformin, work in this way.
    next step is to transfer these studies to humans to determine whether nobiletin has the same positive metabolic effects in human trials.
    and the metabolic syndromes they cause are a huge burden on our health care system, and we have few effective interventions," huff said.
    we need to continue to study the findings of new treatments.
    " () Reference: Nadya M. Morrow et al. The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK, Journal of Lipid Research (2020). DOI: 10.1194/jlr. RA119000542.
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