J Med Food: Wild blueberry extract may affect the formation of blood vessels in the body.

August 6, 2020 // -- In a recent study published in the international journal Journal of Medicinal Food, scientists from the University of Maine and other institutions found that wild blueberry extracts may affect the formation of blood vessels in the body.
when the body experiences damage, cells act, new blood vessels appear through a process called angiogenesic, and cells migrate during a coordinated healing process.
Photo Source: Public Domain's ability to control these mechanisms or potentially accelerate the treatment of a variety of diseases, including cancer and wound healing, polyphenols are a class of natural bioactive compounds present in specific plants that often act as candidate compounds to enhance or slow the progression of disease.
the low shrub blueberries, which grow in eastern Maine, are one of the most abundant sources of polyphenols known; in the paper, the researchers identified the concentrations at which these wild blueberry polyphenols affect cell migration, blood vessels, and inflammation, and explained how the polyphenol compounds can be applied to clinical settings. 'We assessed how two polyphenol compounds found in wild blueberries, anthocyanins and phenolic acids, affect the formation of blood vessels, gene expression, and protein synthesis, all of which are important factors in the tissue healing process,' the
researchers said.
researchers aim to develop a new prototype therapy to enhance wound healing and tissue regeneration to treat hard-to-treat wounds such as burns, or patients with poor circulation due to past diseases such as diabetes; biomedical researchers are also studying the potential of wild blueberry polyphenols to reduce inflammation, which is directly associated with a wide range of chronic diseases, including obesity and heart disease.
final researcher Klimis-Zacas said the findings could help researchers analyze the different effects of these bioactive compounds in in-body models and allow researchers to confirm their function in preclinical studies and develop biomedical prototypes for clinical applications.
will continue to delve deeper into how polyphenols in wild blueberries affect the molecular structure of the body's angiogenesics.
original source: Panagiotis Tsakiroglou et al. Angiogenesis is Differentially Modulated by Anthocyanin and Phenolic Acid Extracts from Wild Blueberry (V. angustifolium) Through PI3K Pathway, Journal of Medicinal Food (2020). doi: 10.1089/jmf.2020.0066.