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February 3, 2021 /--- Multiple Sclerosis (MS) is a chronic, aggressive autoimmune disease of the central nervous system that causes neurological damage and permanent clinical disability.
there are effective treatments for the most common form of MS (relapse-relieving MS), but no effective treatment for progressive MS.
some patients need to stop treatment because of adverse events.
researchers have found that folic acid subjects expressed on the surface of macrophages have the ability to identify foreign bodies and mediate the phagocytostic process.
in autoimmune diseases, this recognition process is impaired, so immune cells target their own tissues.
therefore, folic acid subjects can be used to guide drug targeting for better therapeutic responses.
(Photo: www.pixabay.com) has previously developed an amino butterfly therapy that targets folic acid, which targets folic acid subjects on phagocytosis cells, which has been shown to shut down active inflammation in multiple disease models, but this latest study is the first to demonstrate the efficacy of injection-induced MS chronic carrying models in the brains of rats.
researcher Petri Elo said that when inflammatory activity and lesions decreased significantly, the effect was significant during the chronic period of the disease.
" study shows that the same principle can be used to visualize inflammatory demyelination of central nervous system lesions.
the ideal way to do this is to find a suitable PET tracer with sensitive detection so that patients can be detected in real time and the treatment response monitored," said author Professor Anne Roivainen of the PET Center in Turku.
study also confirmed the presence of folic acid in human phagocytosis cells in patients with chronic inflammatory lesions.
suggests that flic acid-targeted therapy may be effective in reducing active inflammation exacerbated by phagocytosphages caused by chronic aggressive MS in infected individuals.
(Bioon.com) Source: Novel drug attenuates and disease activity in animal model of multiple sclerosis Source: Petri Elo et al. Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis, Journal of Neuroinflammation (2021). DOI: 10.1186/s12974-021-02073-7
