J Oncol: First report!

Breast cancer (BC) is an important cause of premature death in women and one of the most common cancers

Breast cancer diagnosis

LOC105371267, also known as PR-lncRNA1, is a long non-coding RNA (lncRNA) regulated by p53 , which plays a vital role in the pathogenesis of breast cancer

LOC105371267, PR-lncRNA1, p53 LOC105371267

A total of 1,116 female participants (561 BC patients and 555 control patients) were recruited for this study

(P

According to the research criteria, 5 LOC105371267 (rs6499221, rs3931698, rs8044565, rs3852740 and rs111577197) SNPs were screened for genotype testing

(P

The relationship between LOC105371267 SNPs and BC risk was adjusted according to age

LOC105371267 p

The average age of breast cancer diagnosis in China is 45-55 years old, and a stratified analysis was carried out based on the average age of the subjects registered in this research

p

In terms of clinical features, rs3931698 has the possibility of increasing PR-positive BC (GT vs.

p p LOC105371267 p

In the haplotype analysis of the LOC105371267 polymorphism, it was found that only two SNPs, rs3931698 and rs8044565 formed three haplotypes (TC, GT and TT), none of which was related to the incidence of BC ( p >0.

In the haplotype analysis of the LOC105371267 polymorphism, it was found that only two SNPs, rs3931698 and rs8044565 formed three haplotypes (TC, GT and TT), none of which was related to the incidence of BC ( p >0.

According to the results of the FPRP analysis in this study, when the OR value is 2, the BC risk of the rs3931698 subgroup (patients <52 years old) is significantly related, and the FPRP level is <0.

According to the results of the FPRP analysis in this study, when the OR value is 2, the BC risk of the rs3931698 subgroup (patients <52 years old) is significantly related, and the FPRP level is <0.

Finally, this study conducted an MDR analysis to better evaluate the impact of the LOC105371267 variant on the risk of BC

Finally, this study conducted an MDR analysis to better evaluate the impact of the LOC105371267 variant on the risk of BC

In this study, LOC105371267 SNPs rs3931698 and rs6499221 were respectively associated with a decrease and an increase in BC risk in patients <52 years old

LOC105371267 LOC105371267

In conclusion, this study revealed for the first time the influence of rs3931698, rs6499221 and rs3852740 polymorphisms at LOC105371267 on the susceptibility of BC in Han women in northern China , and revealed that LOC105371267 variants may be genetic markers of BC risk, which is conducive to the diagnosis and prediction of BC

This study reveals for the first time the influence of rs3931698, rs6499221 and rs3852740 polymorphisms at LOC105371267 on the susceptibility to BC of Han women in northern China LOC105371267

Original source:

Linna Peng , et al.

Linna Peng , et al.
Linna Peng LOC105371267

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