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    Home > Active Ingredient News > Endocrine System > J Periodontol: Adjuvant use of omega-3 and ASA after periodontal debridement is beneficial for the treatment of periodontitis in patients with type 2 diabetes

    J Periodontol: Adjuvant use of omega-3 and ASA after periodontal debridement is beneficial for the treatment of periodontitis in patients with type 2 diabetes

    • Last Update: 2021-07-31
    • Source: Internet
    • Author: User
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    Supplementation with omega-3 polyunsaturated fatty acids (omega-3 PUFA) and low-dose aspirin (ASA) has been proposed as a host regulatory regimen for the control of chronic inflammatory diseases
    .
    This study aims to investigate the clinical and immunological effects of oral omega-3 PUFA and ASA as adjuvant drugs for periodontal debridement on the treatment of periodontitis in patients with type
    2 diabetes .
    The results of the study have been published in J Periodontol
    .

    Diabetes Immunity

    A total of 75 patients (n = 25/group) were enrolled in the study, and they were randomly assigned to the placebo and periodontal debridement (CG) group.
    After periodontal debridement, they received omega-3 PUFA + ASA (3 grams of fish oil/ Day + 100 mg ASA/day for 2 months) (experimental group [TG]1), or receive omega-3 PUFA + ASA (3 g fish oil/day + 100 mg ASA/day, before periodontal debridement, 2 months) (TG2)

    .
    Baseline (t0), 3 months after periodontal debridement and ω-3 PUFA + ASA or placebo in TG1 and CG groups (t1), and after ω-3 PUFA + ASA (before periodontal debridement) in TG2 group (t1) And periodontal parameters and GCF were collected 6 months (t2) after periodontal debridement (all groups)

    .
    The cytokine levels of GCF were analyzed by multiple ELISA

    .

     

    The results showed that 10 patients (40%) in the TG1 group and 9 patients (36%) in the TG2 group reached the clinical end point of the treatment (less than or equal to 4 sites with a depth of exploration ≥5 mm), while only 4 patients in the CG group (16%)
    .
    The clinical adhesion of the moderate and deep periodontal pockets of TG1 is increased

    .
    The levels of IFN-γ and interleukin (IL)-8 in the two experimental groups decreased over time

    .
    TG1 has a low level of IL-6

    .
    The HbA1c level of TG1 decreased

    .

    In summary, the adjuvant use of omega-3 and ASA after periodontal debridement has clinical and immunological benefits for the treatment of periodontitis in type 2 diabetic patients
    .

     

    Original source:

     

    Nidia C Castro Dos Santos, et al.
    ,
    Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial .
    J Periodontol.
    2020 Oct;91(10):1318-1327.
    doi: 10.
    1002/JPER.
    19-0613.
     

    Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial

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