Supplementation with omega-3 polyunsaturated fatty acids (omega-3 PUFA) and low-dose aspirin (ASA) has been proposed as a host regulatory regimen for the control of chronic inflammatory diseases
This study aims to investigate the clinical and immunological effects of oral omega-3 PUFA and ASA as adjuvant drugs for periodontal debridement on the treatment of periodontitis in patients with type 2 diabetes .
The results of the study have been published in J Periodontol .
A total of 75 patients (n = 25/group) were enrolled in the study, and they were randomly assigned to the placebo and periodontal debridement (CG) group.
After periodontal debridement, they received omega-3 PUFA + ASA (3 grams of fish oil/ Day + 100 mg ASA/day for 2 months) (experimental group [TG]1), or receive omega-3 PUFA + ASA (3 g fish oil/day + 100 mg ASA/day, before periodontal debridement, 2 months) (TG2)
Baseline (t0), 3 months after periodontal debridement and ω-3 PUFA + ASA or placebo in TG1 and CG groups (t1), and after ω-3 PUFA + ASA (before periodontal debridement) in TG2 group (t1) And periodontal parameters and GCF were collected 6 months (t2) after periodontal debridement (all groups)
The cytokine levels of GCF were analyzed by multiple ELISA
The results showed that 10 patients (40%) in the TG1 group and 9 patients (36%) in the TG2 group reached the clinical end point of the treatment (less than or equal to 4 sites with a depth of exploration ≥5 mm), while only 4 patients in the CG group (16%)
The clinical adhesion of the moderate and deep periodontal pockets of TG1 is increased
The levels of IFN-γ and interleukin (IL)-8 in the two experimental groups decreased over time
TG1 has a low level of IL-6
The HbA1c level of TG1 decreased
In summary, the adjuvant use of omega-3 and ASA after periodontal debridement has clinical and immunological benefits for the treatment of periodontitis in type 2 diabetic patients
Nidia C Castro Dos Santos, et al.
, Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial .
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