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It is well known that ectopic lipid accumulation in the kidney (fatty kidney) is a potential driver of diabetic nephropathy, and strict blood sugar control can reduce the risk of diabetic nephropathy
It is well known that ectopic lipid accumulation in the kidney (fatty kidney) is a potential driver of diabetic nephropathy, and strict blood sugar control can reduce the risk of diabetic nephropathy
In this single-center parallel group trial, patients with type 2 diabetes were randomly divided into liraglutide group or placebo group and added standard treatment ( metformin /sulfonylurea derivative/insulin)
Metformin
The baseline analysis included 50 patients with type 2 diabetes (mean age 56.
Results after 26 weeks of blood sugar control
Results after 26 weeks of blood sugar controlLiraglutide or placebo added to the baseline and results after 26 weeks of conventional blood glucose treatment
Liraglutide or placebo added to the baseline and results after 26 weeks of conventional blood glucose treatmentRegardless of the treatment group, after 26 weeks of blood glucose control, the log-transformed RTGC was -0.
Taking into account the existence of GLP1 receptors in the kidney, the direct pathway related to GLP1 activation is to inhibit various damage pathways in the kidney, including oxidative stress (inhibition of nicotinamide adenine dinucleotide phosphate oxidase), inflammation (cytokines and cytokines).
The direct pathway related to GLP1 activation is to inhibit various damage pathways in the kidney, including oxidative stress (inhibition of nicotinamide adenine dinucleotide phosphate oxidase), inflammation (decreased expression of cytokines and chemokines), and fibrosis (The expression of transforming growth factor-β1 and type IV collagen is reduced)
In this exploratory study, it was found that 26 weeks of blood glucose control can reduce RTGC, especially liraglutide
https://doi.
org/10.
1053/j.
jrn.
2020.
09.
006.
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