J Urol: Factors affecting the transition from active surveillance to treatment in patients with prostate cancer

The first choice for the management of low-risk prostate cancer (PC) patients is active surveillance (AS), which can reduce overtreatment of indolent diseases
.

However, current understanding of the relationship between demographic and clinical pathological parameters and the transition from active monitoring to treatment interval is limited

As for the relationship between demographic and clinicopathological parameters and the time interval for switching from active monitoring to treatment, current understanding is limited, and the relationship between demographic and clinicopathological parameters and the time interval for switching from active monitoring to treatment is limited.

Recently, researchers from the United States published an article in the journal J Urol, investigating the demographic and clinicopathological parameters related to the transition from active monitoring to treatment interval in male prostate cancer patients
.

The demographic and clinicopathological parameters related to the transition from active monitoring to treatment interval in male prostate cancer patients were investigated .
The demographic and clinicopathological parameters related to the transition from active monitoring to treatment interval in male prostate cancer patients were investigated.

A total of 7279 patients who were actively monitored were included in the study, and relevant data and biological samples were collected simultaneously
.

Of the 6775 men included in the analysis, 2260 (33.
4%) were converted to treatment during a median follow-up time of 6.
7 years
.

Early conversion to treatment and higher Gleason grade group (GG2 vs GG1, adjusted hazard ratio [aHR]1.

The researchers found no correlation between the time between conversions to treatment and race or genetic ancestry

Relevance of demographic and clinical characteristics to the transition time interval

Relevance of demographic and clinical characteristics to the transition time interval

In summary, the time interval between active monitoring and treatment is related to clinicopathological tumor characteristics
.

In addition, the performance of patients with large GG1 tumors is similar to that of patients with moderate and high-risk tumors

The time interval between active monitoring and treatment is related to clinicopathological tumor characteristics

Original source:

Lauren Folgosa Cooley, Adaeze A Emeka, Travis J Meyers et al.

Factors Associated with Time to Conversion from Active Surveillance to Treatment for Prostate Cancer in a Multi-Institutional Cohort

 

Leave a message here