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    Home > Active Ingredient News > Endocrine System > JACC: The circadian rhythm of natriuretic peptides and its correlation with 24-hour blood pressure fluctuations

    JACC: The circadian rhythm of natriuretic peptides and its correlation with 24-hour blood pressure fluctuations

    • Last Update: 2021-05-20
    • Source: Internet
    • Author: User
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    The diurnal changes of natriuretic peptide (NP) levels and their relationship with the 24-hour blood pressure (BP) rhythm are not yet clear.


    Obese individuals have relative NP deficiency and BP rhythm disorders

    This is a clinical trial aimed at evaluating NP (B-type natriuretic peptide [BNP], central atrial natriuretic peptide [MR-proANP], N-terminal pro-B-type natriuretic peptide [ NT-proBNP]) circadian rhythm, and the correlation between NP rhythm and 24-hour blood pressure rhythm.


    Recruited 18-40 year old healthy, normal blood pressure, wasting (BMI: 18.


    24-hour fluctuations of various indicators in wasting and obese individuals

    24-hour fluctuations of various indicators in wasting and obese individuals

    A total of 52 subjects were screened, and 40 of them (18 were wasting, 22 were obese; 50% were women; 65% were black) completed the study.


    The median range fluctuations (the percentage difference between the maximum and minimum) of various NPs within 24 hours are: MR-proANP: 72.


    Correlation between systolic blood pressure and different NP rhythms

    Correlation between systolic blood pressure and different NP rhythms

    Compared with wasting individuals, in obese individuals, the researchers observed a larger phase difference between the MR-proANP BP rhythm (-4.


    Compared with wasting individuals, in obese individuals, researchers observed a larger phase difference between MR-proANP BP rhythm (-4.


    There is a deviation in the circadian rhythm of NP-BP in obese people, which may be the underlying cause of the circadian BP pattern disorder observed in obese individuals

    Original source:

    Original source:

    Parcha Vibhu, Patel Nirav, Gutierrez Orlando M et al.


    org/10.
    1016/j.
    jacc.
    2021.
    03.
    291">Chronobiology of Natriuretic Peptides? And Blood Pressure in Lean? And? Obese Individuals

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