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The diurnal changes of natriuretic peptide (NP) levels and their relationship with the 24-hour blood pressure (BP) rhythm are not yet clear.
Obese individuals have relative NP deficiency and BP rhythm disorders
This is a clinical trial aimed at evaluating NP (B-type natriuretic peptide [BNP], central atrial natriuretic peptide [MR-proANP], N-terminal pro-B-type natriuretic peptide [ NT-proBNP]) circadian rhythm, and the correlation between NP rhythm and 24-hour blood pressure rhythm.
Recruited 18-40 year old healthy, normal blood pressure, wasting (BMI: 18.
24-hour fluctuations of various indicators in wasting and obese individuals
24-hour fluctuations of various indicators in wasting and obese individualsA total of 52 subjects were screened, and 40 of them (18 were wasting, 22 were obese; 50% were women; 65% were black) completed the study.
The median range fluctuations (the percentage difference between the maximum and minimum) of various NPs within 24 hours are: MR-proANP: 72.
Correlation between systolic blood pressure and different NP rhythms
Correlation between systolic blood pressure and different NP rhythmsCompared with wasting individuals, in obese individuals, the researchers observed a larger phase difference between the MR-proANP BP rhythm (-4.
Compared with wasting individuals, in obese individuals, researchers observed a larger phase difference between MR-proANP BP rhythm (-4.
There is a deviation in the circadian rhythm of NP-BP in obese people, which may be the underlying cause of the circadian BP pattern disorder observed in obese individuals
Original source:
Original source:Parcha Vibhu, Patel Nirav, Gutierrez Orlando M et al.
org/10.
1016/j.
jacc.
2021.
03.
291">Chronobiology of Natriuretic Peptides? And Blood Pressure in Lean? And? Obese Individuals
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