JAD: At this stage before dementia, cognition may be improved by simply supplementing vitamin B!

Identifying the modifiable risk factors that affect cognitive decline is very important for the development of prevention and treatment strategies
.

Paraoxygenase 1 (PON1) is an enzyme related to high-density lipoprotein

Identifying the modifiable risk factors that affect cognitive decline is very important for the development of prevention and treatment strategies

Years ago, British scientists discovered in the latest clinical experiment that taking large doses of vitamin B every day may slow the brain atrophy by half, thereby delaying the course of Alzheimer's disease

Researchers will participate in a randomized, double-blind placebo-controlled trial (VITACOG) of MCI patients (n = 196, 76.
8 years old, 60% women) who will receive daily doses of folic acid (0.
8 mg) and vitamin B12 (0.
5 mg) And B6 (20 mg) (n = 95) or placebo (n = 101) for two years
.

Cognitive abilities are analyzed through neuropsychological tests

The results showed that in the placebo group, the baseline phenylacetate hydrolase (PhAcase) activity of PON1 (but not paraoxygenase activity or PON1 Q192R genotype) was related to overall cognition (MMSE; TICS-m), and verbal incident memory (Hopkins).
Verbal Learning Test-revised: Total recall, HVLT-TR; Delayed recall, HVLT-DR), and attention/processing speed at the end of the study (cue making A and symbolic digital mode test, SDMT)
.

The results showed that in the placebo group, the baseline phenylacetate hydrolase (PhAcase) activity of PON1 (but not paraoxygenase activity or PON1 Q192R genotype) was related to overall cognition (MMSE; TICS-m), and verbal incident memory (Hopkins).
Verbal Learning Test-revised: Total recall, HVLT-TR; Delayed recall, HVLT-DR), and attention/processing speed at the end of the study (cue making A and symbolic digital mode test, SDMT)
.

The results showed that in the placebo group, the baseline phenylacetate hydrolase (PhAcase) activity of PON1 (but not paraoxygenase activity or PON1 Q192R genotype) was related to overall cognition (MMSE; TICS-m), and verbal incident memory (Hopkins).

The population distribution map of POase and PhAcase shows the distribution rate of MCI individuals based on PON1 192QQ, PON1 192QR, and PON1 192RR genotypes
.

In addition to PhAcase, baseline iron and triglycerides can predict MMSE, baseline fatty acids can predict SDMT, baseline anti-N-Hcy-protein autoantibodies can predict TICS-m, SDMT, Trail Making A, and BDNF V66M genotype can predict the end of the study Time HVLT-TR and HVLT-DR scores
.

Among them, B vitamins can eliminate the connection between PON1 and other variables and cognition

B vitamins can eliminate the connection between PON1 and other variables and cognition

In summary, PON1 is a new factor related to cognitive impairment, which can improve the cognitive ability of MCI patients through B vitamins

references:

Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment.

Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment.
J Alzheimers Dis.
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