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    Home > Active Ingredient News > Study of Nervous System > JAHA: Analysis of the curative effect of intravenous thrombolysis before mechanical thrombus removal in acute ischemic stroke

    JAHA: Analysis of the curative effect of intravenous thrombolysis before mechanical thrombus removal in acute ischemic stroke

    • Last Update: 2021-12-03
    • Source: Internet
    • Author: User
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    Mechanical take the first bolt on intravenous thrombolysis whether acute ischemic cerebrovascular stroke functional outcome has the added benefit of not yet clear
    .

    Stroke

    Recently, the heart blood vessels published on the prestigious journal JAHA the areas of disease research article, researchers conducted a meta-analysis, mechanical thrombectomy (dMT) with mechanical thrombectomy more direct intravenous thrombolysis joint bridging (bridging therapy [BT]) Efficacy in patients with acute ischemic stroke
    .

    Heart blood vessels

    Researchers searched the PubMed, Excerpta Medica database, and the Cochrane Central Registry of Randomized Controlled Trials.
    The search time was from January 1, 2003 to April 26, 2021
    .


    The researchers included randomized clinical trials and observational studies that reported the 90-day functional outcome of patients with acute ischemic stroke who received dMT treatment compared to BT treatment


    A total of 12 included studies (3 randomized controlled trials and 9 observational studies) were included in the analysis, with a total of 3924 subjects (mean age 68.
    0 years [SD 13.
    1 years]; 44.
    2% females; 1887 participants Participants accepted dMT, 2037 participants accepted BT)
    .


    A meta-analysis of randomized controlled trials and observational data showed that subjects who received dMT and BT had 90-day functional independence (odds ratio [OR] 1.


    Thus, in the meta-analysis of patients with acute ischemic stroke, researchers found that dMT and BT had no significant difference in 90-day functional outcome or mortality, but dMT had a lower rate of symptomatic intracranial hemorrhage
    .


    These results support the use of dMT instead of intravenous thrombolytic bypass therapy


    In a meta-analysis of patients with acute ischemic stroke, the researchers found that dMT and BT had no significant difference in 90-day functional outcome or mortality, but dMT had a lower rate of symptomatic intracranial hemorrhage


    Original source:

    Houwei Du,et al.


    Intravenous Thrombolysis Before Mechanical Thrombectomy for Acute Ischemic Stroke: A Meta-Analysis In this message
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