JAHA: Assessing Cardiovascular Risk in Older HIV-Infected Individuals: Effects of Hepatitis C Virus Co-infection

Background: Studies in different regions have shown that infected people have a 50 to 75 percent
increased risk of cardiovascular disease compared to non-infected people.

Traditional risk factors for cardiovascular disease (e.

In people infected with PWH and HCV, increasing age is an independent risk factor
for CVD.

Objective: Our goal was to quantify the risk
of major atherosclerotic type 1 myocardial infarction (T1MI) in the United States and Canada with and without chronic hepatitis C between 2000 and 2017.

Methods and Results: We used data
from NA-ACCORD (North American AIDS Cohort Research and Design Collaborative) starting antiretroviral therapy at PWH (ages 40-79 years) from January 1, 2000 to December 31, 2017.

Figure 1 (A) incidence of myocardial infarction and (B) death and 95% ci (per 1000 person-years), classified
by time period and hepatitis C virus co-infection.

Table 1 Crude risk ratio and corrected risk ratio of myocardial infarction-related risk factors in HIV-infected patients in NA-ACCORD studies (N=23 361)

Fig.

Table 2 Adjusted risk ratio of central muscle infarction-related risk factors in NA-ACCORD HIV-infected patients by age (N=23 361)

Conclusion: Hepatitis C virus co-infection has no significant correlation with an increased risk of T1MI; However, with age, people infected with HCV have a greater risk of developing T1MI than non-HCV infected people, and the situation
of HCV infection should be considered when assessing the risk of CVD in older patients with PWH.

Original source:

Lang R, Humes E, Hogan B, et al.