Diabetes is associated with an increased risk of heart failure (HF) and mortality, even after accounting for known cardiovascular risk factors .
Whether cardiac structural and functional abnormalities associated with dysglycemia are sufficient to explain the elevated risk of death or heart failure (HF) remains unclear .
In a recent study published in JAHA, an authoritative journal in the field of cardiovascular disease, researchers analyzed 6,059 participants ( Mean age was 75±5 years; 58% were female; 22% were black)
Participants were divided into three categories: no diabetes, prediabetes, and diabetes (as determined by medical history and glycated hemoglobin values)
We assessed whether diabetes altered the association between echocardiographic measures of cardiac structure and function and the composite outcome of all-cause death or hospitalization for heart failure .
We then estimated the degree of increased risk for the composite outcome associated with diabetes, primarily Explained by cardiac structure and function
5% of the subjects had diabetes
Death or heart failure occurred in 1111 people (18%), 3.
6 deaths per 100 people per year
After accounting for clinical confounders, both cardiac structure and function and indicators of diabetes status were significantly associated with poorer outcomes
While diabetes was consistently associated with higher event risk, it did not significantly alter the association between cardiac abnormalities and risk of death or heart failure, except in subjects with higher relative risk of events with higher left atrial volume (interaction effect P<0.
Measures of cardiac structure and function accounted for a 16% increased risk of diabetes-related death or heart failure
When analyzing subjects without heart disease, the researchers observed similar results
CONCLUSIONS: In a biracial cohort of older adults, cardiac structural and functional abnormalities partly explain the increased risk of diabetes-related events
Original source:Original source:
Cardiac Structure and Function and Diabetes‐Related Risk of Death or Heart Failure in Older Adults .
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