JAHA: China's kaifeng study - prediabetes to restore blood sugar levels on the protection of cardiovascular and cerebrovascular effect

Before DM occurs, patients often experience long periods of prediabetes - impaired blood sugar on an empty stomach or abnormal glucose tolerance.
these two groups of people do not meet the diagnostic criteria for DM, but are already at high risk of type 2 diabetes (T2DM).
, however, there has been no established criteria for the pre-DM parting.
this end, a team of experts from the Institute of Diabetes and Metabolic Diseases (IDM) and the German Diabetes Research Centre (DZD) at the University of Tubingen in Germany recently explored this work and identified six subgroups with characteristics.
results were published in the journal Nature Medicine.
prediabetes is defined as an intermediate metabolic state between normal blood sugar and diabetes, including impaired glucose tolerance and impaired fasting blood sugar.
recent evidence, in addition to diabetics, prediabetes patients are also prone to atherosclerosis cardiovascular disease (CVDs).
studies have shown that higher levels of ancancer blood sugar are associated with a higher risk of CVD in individuals without diabetes.
same time, data from THE DPPOS (Diabetes Prevention Program Results Study) and the Indian Diabetes Prevention Program Special Program showed a reduced risk of developing diabetes in prediabetes who returned to normal blood sugar.
that the prevention of diabetes and its complications is to restore normal blood sugar, not to maintain prediabetes.
is a large-scale Chinese-looking cardiovascular disease epidemiological study conducted in a large-scale group of patients.
recently, a study published in the Journal of the American Heart Association (JAHA) showed that people with prediabetes regain normal blood sugar, which can improve the risk of CVDs and all-cause death such as heart attack and stroke.
study included 14,231 Chinese participants (with an average age of 58.08 years) who did not have myocardial infarction or stroke at the time of the study (2006-2007 and 2008-2009).
A two-year physical examination was conducted based on prediabetes, and participants were divided into three categories based on the results: 1) progression to diabetes;
the risk ratio (HRs) of CVD and all-cause mortality and its 95% CIs using the Cox proportional risk model.
results showed that a total of 879 CVD events (including 180 myocardial infarctions and 713 strokes) and 941 all-cause deaths were recorded during the 8.75-year medium follow-up period.
adjusted for mixed factors, CVD (HR=0.78; 95% CI, 0.64-0.96), myocardial infarction (HR=0.62; 95% CI, 0.96) occurred in people who had prediabecemia to normal blood sugar compared to participants with prediabetery. The risk of stroke (HR-0.79; 95% CI, 0.63-0.98) and all-cause mortality (HR, 0.82; 95% CI, 0.68-0.99) was significantly reduced.
, the reversal Chinese prediabetes to normal blood sugar reduced the risk of future CVD and all-cause mortality in all-cause groups.
can be seen that reversing prediabetes is not only a way to avoid diabetes, but also a prevention of cardiovascular disease.
: Liu X, et al. Reversion From Pre-Diabetes Mellitus to Normoglycemia and Risk of Cardiovascular Disease and All-Cause Mortality in a Chinese Population: A Prospective Cohort Study. J Am Heart Assoc. 2021 Jan 26:e019045. doi: 10.1161/JAHA.120.019045.MedSci Original Source: MedSci Original Copyright Notice: All noted on this website "Source: Met Medical" or "Source: MedSci Original" text, images and audio and video materials, copyrights are owned by Metz Medicine, without authorization, no media, website or individual may reproduce, authorized to reproduce with the words "Source: Mets Medicine".
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