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The biological mechanism of healthy diet and chronic diseases is still unclear
.
Targeted proteomics may help to understand the mechanism of the relationship between diet and chronic diseases
Recently, the heart blood vessels published on the prestigious journal JAHA the areas of disease research article, the researchers evaluated the Framingham Heart Study of 6,360 participants (average age 50 years; 54% female)
.
Researchers used 3 diet quality scores to assess the relationship between diets and 71 cardiovascular disease (CVD)-related proteins: alternative healthy eating index, modified Mediterranean diet score, and modified diet to prevent high blood pressure diet score
Heart blood vessels
After adjusting multiple covariates for all study participants and confirming through internal validation analysis, 30 of the 71 proteins were associated with at least one diet quality score (P<0.
0007)
.
Gene ontology analysis clarified inflammation-related pathways, such as regulating cell killing and neuroinflammatory response (Bonferroni corrected P<0.
After adjusting for multiple potential confounding factors, 4 proteins (B2M[β-2-microglobulin], GDF15 [growth differentiation factor 15], sICAM1[soluble intercellular adhesion molecule 1] and UCMGP[uncarboxylated Matrix Gla-protein]) mediates the correlation between at least one diet quality score and all-cause mortality (median mediation ratio ranges from 8.
6% to 25.
9%)
.
Researchers also observed that GDF15 mediates an association between the alternative healthy eating index and CVD (median mediation ratio is 8.
It can be seen that diet quality is related to new-onset CVD and mortality, as well as circulating CVD-related proteins
.
Several proteins seem to mediate the connection between diet and these outcomes
Diet quality is related to new-onset CVD and mortality, as well as circulating CVD-related proteins
Original source:
Youjin Kim.
Proteins as Mediators of the Association Between Diet Quality and Incident Cardiovascular Disease and All-Cause Mortality: The Framingham Heart Study in this message
